Fertility calculations

Mathematics can help on the jumps of fertility. To this end, the researchers of the Department for artificial insemination at the university and Polyclinic “La Fe” and the Polytechnic University of Valencia (UPV), have developed a mathematical model to optimize embryo selection in which the selection of the best embryos a success of fertilization operation to be achieved.

Sweet Little Baby Girl

Published in the journal mathemathical and computer modeling research, observed that embryos with reduced viability were spotted faster and it was more helpful and allows a more accurate assessment for successful fertility clinic treatment.

The model assesses the embryo quality using two morphological variables: the number of cells and the symmetry and degree of fragmentation of the embryo. The best embryos are those here who have four cells and the symmetry and fragmentation degree one, ie it is symmetrical cells with less than 10% fragmentation. For these, it is most likely that there is a pregnancy. When artificial insemination but not always such embryos are available. Here, the model can assist the embryologist in selecting those embryos, even if they do not meet the optimal conditions, but can lead to pregnancy.

Wikipedia talks briefly about infertility:

Infertility primarily refers to the biological inability of a person to contribute to conception. Infertility may also refer to the state of a woman who is unable to carry a pregnancy to full term. There are many biological causes of infertility, including some that medical intervention can treat.

-Wiki Page

Utilizing preimplantation genetic diagnosis is the best way to utilize this method, although there are also other tools for embryo selection these are not as precise and efficient. “With this model, a fast, accurate and efficient statistical analysis is performed, which improves the predictability of common over other methods significantly.”

This model assesses the embryo Quality Index (EQI) obtained score. The index is calculated on the basis of transferred embryos in relation to the aging woman. Observing which case embryology all embryos with the inverted microscope and determine the number of cells and the degree of the embryo. By observing the development, the embryos are selected for transfer into the uterine cavity, which have the best rate of implantation. In retrospect, the EQI of implanted embryos is calculated. The generated index can predict with the woman age the probability of pregnancy.

The research also showed that the probability of pregnancy decreases with age. Contrary to previous studies, however, this development is not linear. This discovery was made ​​in the Health Research Institute “La Fe” by the professional staff of the hospital “La Fe”, Inmaculada Molina, specialist of the Department of In Vitro Fertilization and Antonio Pellicer, director of the Women’s Hospital area of “La Fe”. Of the UPV were involved Ana Debón by the Centre for Quality and Change Management and Suitberto Cabrera of the group wave phenomena.

Photo Credit: Kjns

Preimplantation Genetic Diagnosis Explained

Women of childbearing age who have a genetic predisposition to diseases, can receive fertility treatments to choose embryos without said genes. This is the core of the genetic preimplantation genetic diagnosis, which is in countries such as Australia, the U.S. and Canada are already a trend.

In a genetic PGD preimplantation genetic diagnosis one can determine prior to its insertion into the uterus, whether that embryo supports any genetic disease by an examination of the embryo. In this way, only healthy embryos are transferred into the womb.

The human genome project has contributed a lot for the accurate determination of the molecular basis of human genetic diseases and many. Also artificial insemination is the discovery that has been a great benefit. With their help, namely a technique could be developed that enables a genetic diagnosis of the embryo prior to its implantation in the uterus.

Portrait of a beautiful young couple smiling together

After careful investigation of the cases they can be applied, for example, in women who have mutations in the genes BRCA 1 and BRCA second. These genes increase the likelihood (60-80%) of developing breast cancer later on. In addition, carriers of BRCA 1 are also more at risk – the numbers are between 30 to 60% – to get ovarian cancer. On the other hand there for a couple in which one partner has this mutation, a 50% chance that even the future child is born with this. With preimplantation genetic inheriting these problems can be avoided.

The procedure of PID is comparable to that of conventional stimulation and differs only by the fact of this, that after two days of fertilization, a biopsy in the cells of the embryo is carried out in the laboratory to determine its chromosomal features. For this purpose, its DNA is examined, where the genes are stored. In this way it can be determined whether the embryo carries a genetic disorder. The affected embryos are then removed and only the healthy inserted into the patient.

At the last meeting of the European Society for Human Reproduction in Istanbul was also the PID issue. The expert for this purpose, Willem Verpoest, invited to more research in the area and presented a survey conducted in 70 European pairs study in which pairs the PID have applied for the elimination of genetic mutations and thereby get completely healthy babies. Overall, there are between 7000 and 8000 genetic disorders caused by mutations, the technology has so much to do.

Photo Credit: Javier Sánchez Mingorance